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Article

Canonical Wnt Signaling Promotes Macrophage Proliferation during Kidney Fibrosis

1 Jan 2018

Abstract excerpt

BACKGROUND: Wnt/β-catenin, an evolutionary conserved signaling pathway, plays an essential role in modulating kidney injury and repair. Our previous studies demonstrated that Wnt/β-catenin signaling could stimulate macrophage M2 polarization and contribute to kidney fibrosis. However, whether canonical Wnt signaling activation leads to macrophage proliferation during kidney fibrosis remains to be determined....

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Share to Chronic Kidney Disease and Diabetes
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PMID: 29998124
DOI: 10.1159/000488984

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