Angiotensin II stimulates the proliferation and biosynthesis of type I collagen in cultured murine mesangial cells.

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Article

Angiotensin II stimulates the proliferation and biosynthesis of type I collagen in cultured murine mesangial cells.

The American journal of pathology - 1 Jan 1992

Wolf G, Haberstroh U, Neilson E G

Abstract excerpt

A murine mesangial cell line (MMC) was established from the glomeruli of SJL mice to study the influence of angiotensin II (ANG II) on their growth and function in a serum-free culture. Murine mesangial cells exhibit the phenotypic characteristics of mesangial cells, including staining for desmin, vimentin, Thy 1, and types I and IV collagen by immunofluorescence. The addition of daily doses of 10(-6) to 10(-11)...

Topics

Angiotensin II
Animals
Cell Division
Cell Line, Transformed
Cells, Cultured
Chimera
Chloramphenicol O-Acetyltransferase
Collagen
Culture Media, Serum-Free
DNA
Desmin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Dose-Response Relationship, Drug

Fluorescent Antibody Technique

Glomerular Mesangium

Insulin

Mice

Phenotype

Proline

Source

Open in PubMed Open full text

Identifiers

PMID: 1731533
PMCID: PMC1886250

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1731533-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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