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Article

New insights into the role and mechanism of Wnt/β‐catenin signalling in kidney fibrosis

1 Oct 2018

Abstract excerpt

Wnt/β-catenin is an evolutionarily conserved, developmental signalling pathway that regulates embryogenesis, injury repair and pathogenesis of human diseases. Dysregulated activation of Wnt/β-catenin is associated with the development and progression of renal fibrotic lesions after injury. Wnt are induced and β-catenin is activated in various models of experimental chronic kidney disease (CKD) and in human...

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PMID: 30298654
DOI: 10.1111/nep.13472

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