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Article

MT1-MMP-mediated basement membrane remodeling modulates renal development.

Experimental cell research - 15 Oct 2010

Riggins Karen S, Mernaugh Glenda, Su Yan, Quaranta Vito, Koshikawa Naohiko, Seiki Motoharu, Pozzi Ambra, Zent Roy

Abstract excerpt

Extracellular matrix (ECM) remodeling regulates multiple cellular functions required for normal development and tissue repair. Matrix metalloproteinases (MMPs) are key mediators of this process and membrane targeted MMPs (MT-MMPs) in particular have been shown to be important in normal development of specific organs. In this study we investigated the role of MT1-MMP in kidney development. We demonstrate that loss...

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Identifiers

PMID: 20727881
DOI: 10.1016/j.yexcr.2010.08.003
PMCID: PMC2945451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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