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miR-34c-5p and CaMKII are involved in aldosterone-induced fibrosis in kidney collecting duct cells

25 Oct 2017

Abstract excerpt

Mineralocorticoids trigger a profibrotic process in the kidney. In mouse cortical collecting duct cells, the present study addressed two main questions: 1) what are microRNAs (miRNAs) and their target genes that are changed by aldosterone? and 2) what do miRNAs, in response to aldosterone, regulate regarding signaling pathways related to fibrosis? A microarray chip assay was done in cells in the absence or...

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PMID: 29070573
DOI: 10.1152/ajprenal.00358.2017

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