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Article

Donor plasmid design for codon and single base genome editing using zinc finger nucleases.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

Pruett-Miller Shondra M, Davis Gregory D

Abstract excerpt

In recent years, CompoZr zinc finger nuclease (ZFN) technology has matured to the point that a user-defined double strand break (DSB) can be placed at virtually any location in the human genome within 50 bp of a desired site. Such high resolution ZFN engineering is well within the conversion tract limitations demarcated by the mammalian DNA repair machinery, resulting in a nearly universal ability to create point...

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PMID: 25408408
DOI: 10.1007/978-1-4939-1862-1_11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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