Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors.

Human gene therapy - 1 Mar 2012

Händel Eva-Maria, Gellhaus Katharina, Khan Kafaitullah, Bednarski Christien, Cornu Tatjana I, Müller-Lerch Felix, Kotin Robert M, Heilbronn Regine, Cathomen Toni

Abstract excerpt

Zinc-finger nucleases (ZFNs) have become a valuable tool for targeted genome engineering. Based on the enzyme's ability to create a site-specific DNA double-strand break, ZFNs promote genome editing by activating the cellular DNA damage response, including homology-directed repair (HDR) and nonhomologous end-joining. The goal of this study was (i) to demonstrate the versatility of combining the ZFN technology...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dependovirus
Share to Endonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Vectors

Share to Genome, Human

Share to Genotype

Share to Green Fluorescent Proteins

Share to Mutation

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 21980922
DOI: 10.1089/hum.2011.140
PMCID: PMC3300077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors.PMID 21980922Read ↗

Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells.Semantic proximity Read ↗

Genome engineering using Adeno-Associated Virus (AAV).Semantic proximity Read ↗

Genome-editing Technologies for Gene and Cell TherapySemantic proximity Read ↗

A novel Cas9 fusion protein promotes targeted genome editing with reduced mutational burden in primary human cellsSemantic proximity Read ↗

Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research ApplicationsSemantic proximity Read ↗

Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential HurdlesSemantic proximity Read ↗

The Current Status of Gene Therapy for the Treatment of CancerSemantic proximity Read ↗

The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting.Semantic proximity Read ↗

Targeted genome modifications using integrase-deficient lentiviral vectors.Semantic proximity Read ↗

In Vivo Genome Editing as a Therapeutic Approach.Semantic proximity Read ↗

Genome and Epigenome Editing to Treat Disorders of the Hematopoietic SystemSemantic proximity Read ↗

Genome-scale analysis of cellular restriction factors that inhibit transgene expression from adeno-associated virus vectorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.