Article
Homology directed correction, a new pathway model for point mutation repair catalyzed by CRISPR-Cas.
Scientific reports - 17 May 2022
Sansbury Brett M, Hewes Amanda M, Tharp Olivia M, Masciarelli Sophia B, Kaouser Salma, Kmiec Eric B
Abstract excerpt
Gene correction is often referred to as the gold standard for precise gene editing and while CRISPR-Cas systems continue to expand the toolbox for clinically relevant genetic repair, mechanistic hurdles still hinder widespread implementation. One of the most prominent challenges to precise CRISPR-directed point mutation repair centers on the prevalence of on-site mutagenesis, wherein insertions and deletions...
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