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Article

Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly.

Genome research - 1 Jul 2009

Kim Hye Joo, Lee Hyung Joo, Kim Hyojin, Cho Seung Woo, Kim Jin-Soo

Abstract excerpt

Broad applications of zinc finger nuclease (ZFN) technology-which allows targeted genome editing-in research, medicine, and biotechnology are hampered by the lack of a convenient, rapid, and publicly available method for the synthesis of functional ZFNs. Here we describe an efficient and easy-to-practice modular-assembly method using publicly available zinc fingers to make ZFNs that can modify the DNA sequences...

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Source

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Identifiers

PMID: 19470664
DOI: 10.1101/gr.089417.108
PMCID: PMC2704428

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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