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A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites

19 Nov 2014

Abstract excerpt

A highly efficacious pre-erythrocytic stage vaccine would be an important tool for the control and elimination of malaria but is currently unavailable. High-level protection in humans can be achieved by experimental immunization with Plasmodium falciparum sporozoites attenuated by radiation or under anti-malarial drug coverage. Immunization with genetically attenuated parasites (GAP) would be an attractive...

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PMID: 25407681
DOI: 10.7554/elife.03582

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