Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A replication-competent late liver stage–attenuated human malaria parasite

2 Jun 2020

Abstract excerpt

Whole-sporozoite vaccines engender sterilizing immunity against malaria in animal models and importantly, in humans. Gene editing allows for the removal of specific parasite genes, enabling generation of genetically attenuated parasite (GAP) strains for vaccination. Using rodent malaria parasites, we have previously shown that late liver stage-arresting replication-competent (LARC) GAPs confer superior protection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Malaria Research and Control
Share to Mosquito-borne diseases and control
Share to Parasites and Host Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32484795
DOI: 10.1172/jci.insight.135589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A replication-competent late liver stage–attenuated human malaria parasitePMID 32484795Read ↗

Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liverSemantic proximity Read ↗

A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletionSemantic proximity Read ↗

A conserved <i>Plasmodium</i> protein that localizes to liver stage nuclei is critical for late liver stage developmentSemantic proximity Read ↗

Preerythrocytic, live-attenuated <i>Plasmodium falciparum</i> vaccine candidates by designSemantic proximity Read ↗

Protective efficacy and safety of liver stage attenuated malaria parasitesSemantic proximity Read ↗

Chemovaccination with a novel antimalarial targeting the late liver stage induces durable immunity against malariaSemantic proximity Read ↗

Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining.Semantic proximity Read ↗

Genetically modified Plasmodium parasites as a protective experimental malaria vaccine.Semantic proximity Read ↗

Complete Plasmodium falciparum liver-stage development in liver-chimeric miceSemantic proximity Read ↗

Development of an Ectopic huLiver Model for <i>Plasmodium</i> Liver Stage InfectionSemantic proximity Read ↗

Direct type I Interferon signaling in hepatocytes control malariaSemantic proximity Read ↗

A Conditional Cas9 System for Stage-Specific Gene Editing in <i>P. falciparum</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.