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A Next-generation Genetically Attenuated Plasmodium falciparum Parasite Created by Triple Gene Deletion

14 May 2014

Abstract excerpt

Immunization with live-attenuated Plasmodium sporozoites completely protects against malaria infection. Genetic engineering offers a versatile platform to create live-attenuated sporozoite vaccine candidates. We previously generated a genetically attenuated parasite (GAP) by deleting the P52 and P36 genes in the NF54 wild-type (WT) strain of Plasmodium falciparum (Pf p52(-)/p36(-) GAP). Preclinical assessment of...

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PMID: 24827907
DOI: 10.1038/mt.2014.85

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