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Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver

4 Nov 2022

Abstract excerpt

Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal malaria models and in humans. A recent clinical trial with a WSp vaccine comprising genetically attenuated parasites (GAP) which arrest growth early in the liver (PfSPZ-GA1), showed that GAPs can be safely administered to humans and immunogenicity is comparable to radiation-attenuated PfSPZ Vaccine. GAPs that arrest late in the...

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PMID: 36333336
DOI: 10.1038/s41541-022-00558-x

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