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A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion

21 Mar 2024

Abstract excerpt

Abstract Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with antimalarial drugs (PfSPZ-CVac), confers superior sterilizing protection against infection when compared to vaccination with replication-deficient, radiation-attenuated PfSPZ. However, the requirement for drug administration constitutes a major limitation for PfSPZ-CVac. To obviate this limitation, we generated...

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PMID: 38514791
DOI: 10.1038/s44321-024-00057-7

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