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Article

Protective efficacy and safety of liver stage attenuated malaria parasites

31 May 2016

Abstract excerpt

During the clinically silent liver stage of a Plasmodium infection the parasite replicates from a single sporozoite into thousands of merozoites. Infection of humans and rodents with large numbers of sporozoites that arrest their development within the liver can cause sterile protection from subsequent infections. Disruption of genes essential for liver stage development of rodent malaria parasites has yielded a...

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PMID: 27241521
DOI: 10.1038/srep26824

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