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Optimization of an in vivo model to study immunity to Plasmodium falciparum pre-erythrocytic stages

1 Dec 2019

Abstract excerpt

BACKGROUND: The circumsporozoite protein (CSP) of Plasmodium is a key surface antigen that induces antibodies and T-cells, conferring immune protection in animal models and humans. However, much of the work on CSP and immunity has been developed based on studies using rodent or non-human primate CSP antigens, which may not be entirely translatable to CSP expressed by human malaria parasites, especially...

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PMID: 31849326
DOI: 10.1186/s12936-019-3055-9

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