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Article

Epistasis for quantitative traits in Drosophila.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

Mackay Trudy F C

Abstract excerpt

The role of gene-gene interactions in the genetic architecture of quantitative traits is controversial, despite the biological plausibility of nonlinear molecular interactions underpinning variation in quantitative traits. In strictly outbreeding populations, genetic architecture is inferred indirectly by estimating variance components; however, failure to detect epistatic variance does not mean lack of epistatic...

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PMID: 25403527
DOI: 10.1007/978-1-4939-2155-3_4

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