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Article

The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross.

Nature communications - 18 Mar 2022

Matsui Takeshi, Mullis Martin N, Roy Kevin R, Hale Joseph J, Schell Rachel, Levy Sasha F, Ehrenreich Ian M

Abstract excerpt

In diploid species, genetic loci can show additive, dominance, and epistatic effects. To characterize the contributions of these different types of genetic effects to heritable traits, we use a double barcoding system to generate and phenotype a panel of ~200,000 diploid yeast strains that can be partitioned into hundreds of interrelated families. This experiment enables the detection of thousands of epistatic...

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Identifiers

PMID: 35304450
DOI: 10.1038/s41467-022-29111-z
PMCID: PMC8933436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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