Article
Epistasis dominates the genetic architecture of Drosophila quantitative traits.
Proceedings of the National Academy of Sciences of the United States of America - 25 Sept 2012
Huang Wen, Richards Stephen, Carbone Mary Anna, Zhu Dianhui, Anholt Robert R H, Ayroles Julien F, Duncan Laura, Jordan Katherine W, Lawrence Faye, Magwire Michael M, Warner Crystal B, Blankenburg Kerstin, Han Yi, Javaid Mehwish, Jayaseelan Joy, Jhangiani Shalini N, Muzny Donna, Ongeri Fiona, Perales Lora, Wu Yuan-Qing, Zhang Yiqing, Zou Xiaoyan, Stone Eric A, Gibbs Richard A, Mackay Trudy F C
Abstract excerpt
Epistasis-nonlinear genetic interactions between polymorphic loci-is the genetic basis of canalization and speciation, and epistatic interactions can be used to infer genetic networks affecting quantitative traits. However, the role that epistasis plays in the genetic architecture of quantitative traits is controversial. Here, we compared the genetic architecture of three Drosophila life history traits in the...
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