Article
Genetic incompatibilities are widespread within species.
Nature - 5 Dec 2013
Corbett-Detig Russell B, Zhou Jun, Clark Andrew G, Hartl Daniel L, Ayroles Julien F
Abstract excerpt
The importance of epistasis--non-additive interactions between alleles--in shaping population fitness has long been a controversial topic, hampered in part by lack of empirical evidence. Traditionally, epistasis is inferred on the basis of non-independence of genotypic values between loci for a given trait. However, epistasis for fitness should also have a genomic footprint. To capture this signal, we have...
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