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Article

Pleiotropy, epistasis and the genetic architecture of quantitative traits.

Nature reviews. Genetics - 1 Sept 2024

Mackay Trudy F C, Anholt Robert R H

Abstract excerpt

Pleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis (whereby non-linear interactions between genetic polymorphisms affect the same trait) are fundamental aspects of the genetic architecture of quantitative traits. Recent advances in the ability to characterize the effects of polymorphic variants on molecular and organismal phenotypes in human and model organism populations have...

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Source

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Identifiers

PMID: 38565962
DOI: 10.1038/s41576-024-00711-3
PMCID: PMC11330371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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