Article
Considerations in the search for epistasis.
Genome biology - 19 Nov 2024
Balvert Marleen, Cooper-Knock Johnathan, Stamp Julian, Byrne Ross P, Mourragui Soufiane, van Gils Juami, Benonisdottir Stefania, Schlüter Johannes, Kenna Kevin, Abeln Sanne, Iacoangeli Alfredo, Daub Joséphine T, Browning Brian L, Taş Gizem, Hu Jiajing, Wang Yan, Alhathli Elham, Harvey Calum, Pianesi Luna, Schulte Sara C, González-Domínguez Jorge, Garrisson Erik, Snyder Michael P, Schönhuth Alexander, Sng Letitia M F, Twine Natalie A
Abstract excerpt
Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units. Such interactions are both biologically plausible and good candidates to explain observations which are not fully explained by an additive heritability model. However, the search for epistasis has so far largely failed to...
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