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Article

Generation of site-specific mutations in the rat genome via CRISPR/Cas9.

Methods in enzymology - 1 Jan 2014

Guan Yuting, Shao Yanjiao, Li Dali, Liu Mingyao

Abstract excerpt

The laboratory rat is a valuable model organism for basic biological studies and drug development. However, due to the lack of genetic tools for site-specific genetic modification in the rat genome, more and more researchers chose the mouse as their favored mammalian models due to the sophisticated embryonic stem cell-based gene-targeting techniques available. Recently, engineered nucleases, including zinc finger...

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PMID: 25398346
DOI: 10.1016/B978-0-12-801185-0.00014-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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