Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease.

Nucleic acids research - 1 Nov 2013

Fujii Wataru, Kawasaki Kurenai, Sugiura Koji, Naito Kunihiko

Abstract excerpt

The generation of genome-modified animals is a powerful approach to analyze gene functions. The CAS9/guide RNA (gRNA) system is expected to become widely used for the efficient generation of genome-modified animals, but detailed studies on optimum conditions and availability are limited. In the p...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Deletion
Share to CRISPR-Associated Proteins
Share to Endodeoxyribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Engineering

Share to Genome

Share to Mice, Inbred ICR

Share to RNA, Small Untranslated

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 23997119
DOI: 10.1093/nar/gkt772
PMCID: PMC3814358

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23997119-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease.PMID 23997119Read ↗

Genome editing for the reproduction and remedy of human diseases in mice.Semantic proximity Read ↗

Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases.Semantic proximity Read ↗

A non-inheritable maternal Cas9-based multiple-gene editing system in mice.Semantic proximity Read ↗

Crispr/cas-mediated Genome Editing in Mice for the Development of Drug Delivery MechanismSemantic proximity Read ↗

Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology.Semantic proximity Read ↗

Creation of mutant mice with megabase-sized deletions containing custom-designed breakpoints by means of the CRISPR/Cas9 system.Semantic proximity Read ↗

Feasibility for a large scale mouse mutagenesis by injecting CRISPR/Cas plasmid into zygotes.Semantic proximity Read ↗

Generation of an Oocyte-Specific Cas9 Transgenic Mouse for Genome Editing.Semantic proximity Read ↗

Highly Efficient Mouse Genome Editing by CRISPR Ribonucleoprotein Electroporation of Zygotes.Semantic proximity Read ↗

Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein.Semantic proximity Read ↗

Generation of site-specific mutations in the rat genome via CRISPR/Cas9.Semantic proximity Read ↗

Genetic engineering as a tool for the generation of mouse models to understand disease phenotypes and gene function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.