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Article

Successful production of genome-edited rats by the rGONAD method.

BMC biotechnology - 2 Apr 2018

Kobayashi Tomoe, Namba Masumi, Koyano Takayuki, Fukushima Masaki, Sato Masahiro, Ohtsuka Masato, Matsuyama Makoto

Abstract excerpt

BACKGROUND: Recent progress in development of the CRISPR/Cas9 system has been shown to be an efficient gene-editing technology in various organisms. We recently developed a novel method called Genome-editing via Oviductal Nucleic Acids Delivery (GONAD) in mice; a novel in vivo genome editing system that does not require ex vivo handling of embryos, and this technology is newly developed and renamed as "improved...

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Identifiers

PMID: 29606116
DOI: 10.1186/s12896-018-0430-5
PMCID: PMC5879918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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