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Article

The impact of recombination on human mutation load and disease.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Dec 2017

Alves Isabel, Houle Armande Ang, Hussin Julie G, Awadalla Philip

Abstract excerpt

Recombination promotes genomic integrity among cells and tissues through double-strand break repair, and is critical for gamete formation and fertility through a strict regulation of the molecular mechanisms associated with proper chromosomal disjunction. In humans, congenital defects and recurrent structural abnormalities can be attributed to aberrant meiotic recombination. Moreover, mutations affecting genes...

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Identifiers

PMID: 29109227
DOI: 10.1098/rstb.2016.0465
PMCID: PMC5698626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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