Article
Non-crossover gene conversions show strong GC bias and unexpected clustering in humans.
eLife - 25 Mar 2015
Williams Amy L, Genovese Giulio, Dyer Thomas, Altemose Nicolas, Truax Katherine, Jun Goo, Patterson Nick, Myers Simon R, Curran Joanne E, Duggirala Ravi, Blangero John, Reich David, Przeworski Molly
Abstract excerpt
Although the past decade has seen tremendous progress in our understanding of fine-scale recombination, little is known about non-crossover (NCO) gene conversion. We report the first genome-wide study of NCO events in humans. Using SNP array data from 98 meioses, we identified 103 sites affected by NCO, of which 50/52 were confirmed in sequence data. Overlap with double strand break (DSB) hotspots indicates that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.