Article
A high-resolution recombination map of the human genome.
Nature genetics - 1 Jul 2002
Kong Augustine, Gudbjartsson Daniel F, Sainz Jesus, Jonsdottir Gudrun M, Gudjonsson Sigurjon A, Richardsson Bjorgvin, Sigurdardottir Sigrun, Barnard John, Hallbeck Bjorn, Masson Gisli, Shlien Adam, Palsson Stefan T, Frigge Michael L, Thorgeirsson Thorgeir E, Gulcher Jeffrey R, Stefansson Kari
Abstract excerpt
Determination of recombination rates across the human genome has been constrained by the limited resolution and accuracy of existing genetic maps and the draft genome sequence. We have genotyped 5,136 microsatellite markers for 146 families, with a total of 1,257 meiotic events, to build a high-resolution genetic map meant to: (i) improve the genetic order of polymorphic markers; (ii) improve the precision of...
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