Article

Non-crossover gene conversions show strong GC bias and unexpected clustering in humans

2014-09-16

Abstract excerpt

Although the past decade has seen tremendous progress in our understanding of fine-scale recombination, little is known about non-crossover (NCO) gene conversion. We report the first genome-wide study of NCO events in humans. Using SNP array data from 98 meioses, we identified 103 sites affected by NCO, of which 50/52 were confirmed in sequence data. Overlap with double strand break (DSB) hotspots indicates that t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 42461a8b-70ef-5ac9-a69c-96e8b1e97cd1
DOI: 10.1101/009175

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Non-crossover gene conversions show strong GC bias and unexpected clustering in humansDOI 10.1101/009175Read

Non-crossover gene conversions show strong GC bias and unexpected clustering in humans.Semantic proximity Read

Insights into non-crossover recombination from long-read sperm sequencingSemantic proximity Read

The rate of meiotic gene conversion varies by sex and age.Semantic proximity Read

Insights into gene conversion and crossing-over processes from long-read sequencing of human, chimpanzee and gorilla testes and spermSemantic proximity Read

DNA recombination. Recombination initiation maps of individual human genomes.Semantic proximity Read

Complete human recombination maps.Semantic proximity Read

Preaching about the converted: how meiotic gene conversion influences genomic diversity.Semantic proximity Read

1000 human genomes carry widespread signatures of GC biased gene conversion.Semantic proximity Read

Estimating gene conversion rates from population data using multi-individual identity by descentSemantic proximity Read

Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination.Semantic proximity Read

Modeling the length distribution of gene conversion tracts in humans from the UK Biobank sequence dataSemantic proximity Read

Estimating gene conversion rates from population data using multi-individual identity by descent.Semantic proximity Read