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Article

Decoupling of evolutionary changes in transcription factor binding and gene expression in mammals.

Genome research - 1 Feb 2015

Wong Emily S, Thybert David, Schmitt Bianca M, Stefflova Klara, Odom Duncan T, Flicek Paul

Abstract excerpt

To understand the evolutionary dynamics between transcription factor (TF) binding and gene expression in mammals, we compared transcriptional output and the binding intensities for three tissue-specific TFs in livers from four closely related mouse species. For each transcription factor, TF-dependent genes and the TF binding sites most likely to influence mRNA expression were identified by comparing mRNA...

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Identifiers

PMID: 25394363
DOI: 10.1101/gr.177840.114
PMCID: PMC4315291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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