Tracing the evolution of lineage-specific transcription factor binding sites in a birth-death framework.

Abstract excerpt

Changes in cis-regulatory element composition that result in novel patterns of gene expression are thought to be a major contributor to the evolution of lineage-specific traits. Although transcription factor binding events show substantial variation across species, most computational approaches to study regulatory elements focus primarily upon highly conserved sites, and rely heavily upon multiple sequence...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Computational Biology
• Share to Evolution, Molecular