Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of cross-disorder polygenic risk on frontal brain activation with specific effect of schizophrenia risk.

Schizophrenia research - 1 Feb 2015

Whalley Heather C, Hall Lynsey, Romaniuk Liana, Macdonald Alix, Lawrie Stephen M, Sussmann Jessika E, McIntosh Andrew M

Abstract excerpt

Evidence suggests that there is shared genetic aetiology across the major psychiatric disorders conferred by additive effects of many common variants. Measuring their joint effects on brain function may identify common neural risk mechanisms. We investigated the effects of a cross-disorder polygenic risk score (PGRS), based on additive effects of genetic susceptibility to the five major psychiatric disorders, on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Attention Deficit Disorder with Hyperactivity
Share to Autistic Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bipolar Disorder

Share to Depressive Disorder, Major

Share to Frontal Lobe

Share to Functional Laterality

Share to Interview, Psychological

Share to Psychiatric Status Rating Scales

Source

Open in PubMed Open full text

Identifiers

PMID: 25468172
DOI: 10.1016/j.schres.2014.10.046
PMCID: PMC4396692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of cross-disorder polygenic risk on frontal brain activation with specific effect of schizophrenia risk.PMID 25468172Read ↗

A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder.Semantic proximity Read ↗

Polygenic risk for schizophrenia associated with working memory-related prefrontal brain activation in patients with schizophrenia and healthy controls.Semantic proximity Read ↗

The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI.Semantic proximity Read ↗

Derivation and utility of schizophrenia polygenic risk associated multimodal MRI frontotemporal network.Semantic proximity Read ↗

Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations.Semantic proximity Read ↗

A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.Semantic proximity Read ↗

Prefrontal inefficiency is associated with polygenic risk for schizophrenia.Semantic proximity Read ↗

Genetic overlap between schizophrenia and selective components of executive functionSemantic proximity Read ↗

Familial Risk for Schizophrenia vs Bipolar Disorder and Task-Based Neural Activation: A functional Magnetic Resonance Imaging Meta-Analysis.Semantic proximity Read ↗

Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.Semantic proximity Read ↗

Executive functioning-related brain abnormalities associated with the genetic liability for schizophrenia: an activation likelihood estimation meta-analysis.Semantic proximity Read ↗

Polygenic risk for schizophrenia, transition and cortical gyrification: a high-risk study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.