Article
Cumulative genetic risk and prefrontal activity in patients with schizophrenia.
Schizophrenia bulletin - 1 May 2013
Walton Esther, Turner Jessica, Gollub Randy L, Manoach Dara S, Yendiki Anastasia, Ho Beng-Choon, Sponheim Scott R, Calhoun Vince D, Ehrlich Stefan
Abstract excerpt
The lack of consistency of genetic associations in highly heritable mental illnesses, such as schizophrenia, remains a challenge in molecular psychiatry. Because clinical phenotypes for psychiatric disorders are often ill defined, considerable effort has been made to relate genetic polymorphisms to underlying physiological aspects of schizophrenia (so called intermediate phenotypes), that may be more reliable....
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