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Article

Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function.

G3 (Bethesda, Md.) - 11 Nov 2014

Tang Baiqing, Kadariya Yuwaraj, Chen Yibai, Slifker Michael, Kruger Warren D

Abstract excerpt

Methylthioadenosine Phosphorylase (MTAP) is a tumor suppressor gene that is frequently deleted in human cancers and encodes an enzyme responsible for the catabolism of the polyamine byproduct 5'deoxy-5'-methylthioadenosine (MTA). To elucidate the mechanism by which MTAP inhibits tumor formation, we have reintroduced MTAP into MTAP-deleted HT1080 fibrosarcoma cells. Expression of MTAP resulted in a variety of...

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Source

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Identifiers

PMID: 25387827
DOI: 10.1534/g3.114.014555
PMCID: PMC4291467

Genes

MTAP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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