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Specific Targeting of MTAP -Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-Methylthioadenosine

29 May 2018

Abstract excerpt

Abstract Homozygous deletion of the methylthioadenosine phosphorylase (MTAP) gene is a frequent event in a wide variety of human cancers and is a possible molecular target for therapy. One potential therapeutic strategy to target MTAP-deleted tumors involves combining toxic purine analogues such as 6′-thioguanine (6TG) or 2′-fluoroadenine (2FA) with the MTAP substrate 5′-deoxy-5′-methylthioadenosine (MTA). The...

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PMID: 29844120
DOI: 10.1158/0008-5472.can-18-0814

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