Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma.

The American journal of pathology - 1 Aug 2003

Behrmann Iris, Wallner Susanne, Komyod Waraporn, Heinrich Peter C, Schuierer Marion, Buettner Reinhard, Bosserhoff Anja-Katrin

Abstract excerpt

Homozygous deletions of human chromosomal region 9p21 occur frequently in malignant melanoma and are associated with the loss of the tumor suppressor genes p16(INK4a) and p15(INK4b). In the same chromosomal region the methylthioadenosine phosphorylase (MTAP) gene is localized and therefore may also serve as a tumor suppressor gene. The aim of this study was to analyze MTAP mutations and expression patterns in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Neoplastic
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanocytes

Share to Melanoma

Share to Methylation

Share to Nevus, Pigmented

Share to Purine-Nucleoside Phosphorylase

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 12875987
DOI: 10.1016/S0002-9440(10)63695-4
PMCID: PMC1868213

Genes

MTAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma.PMID 12875987Read ↗

Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma.Semantic proximity Read ↗

Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma.Semantic proximity Read ↗

Codeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-α1, interferon-β1, and other 9p21 markers in human malignant cell linesSemantic proximity Read ↗

Loss of MTAP expression is strongly linked to homozygous 9p21 deletion, unfavorable tumor phenotype, and noninflamed microenvironment in urothelial bladder cancer.Semantic proximity Read ↗

Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function.Semantic proximity Read ↗

Specific Targeting of MTAP -Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-MethylthioadenosineSemantic proximity Read ↗

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cellsSemantic proximity Read ↗

Selective Killing of Tumors Deficient in Methylthioadenosine Phosphorylase: A Novel StrategySemantic proximity Read ↗

Homozygous deletions within human chromosome band 9p21 in melanoma.Semantic proximity Read ↗

Over-expression of MSG1 transcriptional co-activator increases melanin in B16 melanoma cells: a possible role for MSG1 in melanogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.