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Selective Killing of Tumors Deficient in Methylthioadenosine Phosphorylase: A Novel Strategy

28 May 2009

Abstract excerpt

BACKGROUND: The gene for methylthioadenosine phosphorylase (MTAP) lies on 9p21, close to the gene CDKN2A that encodes the tumor suppressor proteins p16 and p14ARF. MTAP and CDKN2A are homozygously co-deleted, with a frequency of 35 to 70%, in lung and pancreatic cancer, glioblastoma, osteosarcoma, soft-tissue sarcoma, mesothelioma, and T-cell acute lymphoblastic leukemia. In normal cells, but not in tumor cells...

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PMID: 19478948
DOI: 10.1371/journal.pone.0005735

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Selective Killing of Tumors Deficient in Methylthioadenosine Phosphorylase: A Novel StrategyPMID 19478948Read ↗

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