Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defects in methylthioadenosine phosphorylase are associated with but not responsible for methionine-dependent tumor cell growth.

Cancer research - 1 Oct 2000

Tang B, Li Y N, Kruger W D

Abstract excerpt

A large proportion of human tumor-derived cell lines and primary tumor cells show methionine-dependent growth. This phenomenon refers to the ability of cells to grow in media containing methionine and the inability of cells to grow in media supplemented with methionine's precursor, homocysteine (Hcy). Methionine can be formed by two different pathways, the recycling pathway and the salvage pathway. To discover...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Cell Division

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Gene Deletion

Share to Homocysteine

Share to Methionine

Share to Purine-Nucleoside Phosphorylase

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 11034100

Genes

MTAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defects in methylthioadenosine phosphorylase are associated with but not responsible for methionine-dependent tumor cell growth.PMID 11034100Read ↗

Changes in cobalamin metabolism are associated with the altered methionine auxotrophy of highly growth autonomous human melanoma cells.Semantic proximity Read ↗

The role of B12 deficiency and methionine synthase in methionine-dependent cancer cellsSemantic proximity Read ↗

Methionine dependence in cancer cells due to lack of B <sub>12</sub> -dependent methionine synthase activitySemantic proximity Read ↗

Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer.Semantic proximity Read ↗

Epigenetic modification of the gene for the vitamin B(12) chaperone MMACHC can result in increased tumorigenicity and methionine dependence.Semantic proximity Read ↗

Methionine dependency of malignant tumors: a possible approach for therapy.Semantic proximity Read ↗

Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odysseySemantic proximity Read ↗

Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites.Semantic proximity Read ↗

The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferationSemantic proximity Read ↗

A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension.Semantic proximity Read ↗

Reversion to a homocysteine-responsive phenotype in a human melanoma cell line is associated with diminished growth potential and increased methionine biosynthesis.Semantic proximity Read ↗

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.