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Article

Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites.

The Journal of biological chemistry - 12 Dec 2003

Subhi Ahmad L, Diegelman Paula, Porter Carl W, Tang Baiqing, Lu Zichun J, Markham George D, Kruger Warren D

Abstract excerpt

The gene encoding methylthioadenosine phosphorylase (MTAP), the initial enzyme in the methionine salvage pathway, is deleted in a variety of human tumors and acts as a tumor suppressor gene in cell culture (Christopher, S. A., Diegelman, P., Porter, C. W., and Kruger, W. D. (2002) Cancer Res. 62, 6639-6644). Overexpression of the polyamine biosynthetic enzyme ornithine decarboxylase (ODC) is frequently observed...

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Share to Chromatography, High Pressure Liquid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14506228
DOI: 10.1074/jbc.M308451200

Genes

MTAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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