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Article

Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation.

Oncogene - 26 Jun 2008

Tucker L A, Zhang Q, Sheppard G S, Lou P, Jiang F, McKeegan E, Lesniewski R, Davidsen S K, Bell R L, Wang J

Abstract excerpt

Methionine aminopeptidase-2 (MetAP2) processes N-terminal methionine from nascent cellular proteins. Inhibition of MetAP2 has been shown to block angiogenesis and suppress tumor growth in preclinical tumor models. However, the biological role of MetAP2 in cancer is not well understood. We examined the effect of three distinct chemical classes of MetAP2 inhibitors on the growth of a panel of human cancer cells in...

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Identifiers

PMID: 18264137
DOI: 10.1038/onc.2008.14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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