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Article

Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma.

Carcinogenesis - 1 Jan 2006

Hellerbrand Claus, Mühlbauer Marcus, Wallner Susanne, Schuierer Marion, Behrmann Iris, Bataille Frauke, Weiss Thomas, Schölmerich Jürgen, Bosserhoff Anja-Katrin

Abstract excerpt

The methylthioadenosine phosphorylase (MTAP) gene is localized in the chromosomal region 9p21. Here, frequently homozygous deletions occur in several kinds of cancer associated with the loss of tumour suppressor genes as p16 and p15. The aim of this study was to analyse MTAP expression in hepatocellular carcinoma (HCC) and to get an insight into the regulation and functional role of MTAP in hepatocancerogenesis....

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Source

Identifiers

PMID: 16081515
DOI: 10.1093/carcin/bgi201

Genes

MTAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma.PMID 16081515Read ↗

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