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Article

Molecular characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase-deficient mutant clones of murine lymphoma cell line R1.1.

Cancer science - 1 Jun 2003

Kadariya Yuwaraj, Nishioka Junji, Nakamura Akiko, Kato-Nakazawa Keiko, Nobori Tsutomu

Abstract excerpt

5'-Deoxy-5'-methylthioadenosine phosphorylase (MTAP), the polyamine and purine metabolic enzyme, is ubiquitously expressed in normal human tissues and cells, but is deficient in a variety of human and murine malignant cell lines. MTAP-deficient mutants were previously selected from murine lymphoma cell line R1.1 that contains abundant MTAP activity, to analyze the metabolic consequences of MTAP deficiency. Two...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Purine-Nucleoside Phosphorylase

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Messenger

Share to RNA, Neoplasm

Share to Sequence Homology, Amino Acid

Share to Tumor Cells, Cultured

Source

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Identifiers

PMID: 12824877
DOI: 10.1111/j.1349-7006.2003.tb01476.x
PMCID: PMC11160232

Genes

MTAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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