Article
IL-17A, IL-17F and IL-23R Gene Polymorphisms in Polish Patients with Rheumatoid Arthritis.
Archivum immunologiae et therapiae experimentalis - 1 Jun 2015
Bogunia-Kubik Katarzyna, Świerkot Jerzy, Malak Anna, Wysoczańska Barbara, Nowak Beata, Białowąs Katarzyna, Gębura Katarzyna, Korman Lucyna, Wiland Piotr
Abstract excerpt
Among the complex network of inflammatory cells involved in the pathogenesis of rheumatoid arthritis (RA), Th17 cells have recently been identified as key cells in the promotion of autoimmune processes, and joint destruction. The IL-23/Th17 signalling pathway, consisting of IL-23/IL-23R, IL-17A and IL-17F encoding genes, represents a candidate way for RA development with possible involvement in disease...
Topics
- Adolescent
- Adult
- Aged
- Animals
- Antirheumatic Agents
- Arthritis, Rheumatoid
- Disease Progression
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans