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Article

IL-23R rs11209026 polymorphism modulates IL-17A expression in patients with rheumatoid arthritis.

Genes and immunity - 1 Apr 2012

Hazlett J, Stamp L K, Merriman T, Highton J, Hessian P A

Abstract excerpt

The interleukin (IL)-17/IL-23 axis is an important pro-inflammatory pathway in rheumatoid arthritis (RA). IL-23 maintains CD4(+) T-helper 17 (Th(17)) cells, whereas IL-12 negates IL-17A production by promoting Th(1)-cell differentiation. We sought evidence for any effect of polymorphisms within the interleukin-23 receptor (IL-23R), IL-12 or IL-21 genes on serum cytokine concentrations in 81 patients with RA....

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PMID: 22130325
DOI: 10.1038/gene.2011.80

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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