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Are genetic variations in IL‐21–IL‐23R–IL‐17A cytokine axis involved in a pathogenic pathway of rheumatoid arthritis? Bayesian hierarchical meta‐analysis

28 Mar 2019

Abstract excerpt

Inflammatory cytokines have been established to be involved in the pathogenesis of rheumatoid arthritis (RA). The genetic polymorphisms in the interleukin (IL) 23 receptor (IL23R), IL21, and IL17 have been associated with RA risk. However, there is no conclusive understanding of the genes encoding the immunoinflammatory IL-21-IL-23R-IL-17A pathway in RA aetiopathogenesis. This meta-analysis was conducted to...

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PMID: 30924147
DOI: 10.1002/jcp.28495

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