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The Influence of Polymorphisms of Interleukin-17A and -17F Genes on Susceptibility and Activity of Rheumatoid Arthritis.

Genetic testing and molecular biomarkers - 1 Aug 2015

Erkol İnal Esra, Görükmez Orhan, Dündar Ümit, Görükmez Özlem, Yener Mahmut, Özemri Sağ Şebnem, Yakut Tahsin

Abstract excerpt

BACKGROUND: The roles of interleukin (IL)-17A and IL-17F in the pathogenesis of rheumatoid arthritis (RA) have been previously studied. However, the relationships between polymorphisms (IL-17A G197A, the IL-17F 7488A/G, and the IL-17F 7383A/G) of these genes with RA have not been clarified yet. AIMS: To investigate the impacts of these polymorphisms on the severity and susceptibility of RA in a Turkish...

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PMID: 26154773
DOI: 10.1089/gtmb.2015.0064

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