Article
IL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis.
PloS one - 1 Jan 2018
Dhaouadi Tarak, Chahbi Mayssa, Haouami Youssra, Sfar Imen, Abdelmoula Leila, Ben Abdallah Taieb, Gorgi Yousr
Abstract excerpt
BACKGROUND: Interleukin-17 (IL-17), a cytokine mainly secreted by Th17 cells, seems to play a significant role in the pathogenesis of rheumatoid arthritis (RA). Functional genetic polymorphisms in IL-17 and its receptor genes can influence either qualitatively or quantitatively their functions. Therefore, we aimed to study the impact of IL17-A and IL17RC polymorphisms on plasma level of IL-17 and RA...
Topics
- Adult
- Alleles
- Area Under Curve
- Arthritis, Rheumatoid
- Black People
- Case-Control Studies
- Disease Susceptibility
- Female
- Genotype
- Humans
- Interleukin-17