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Article

Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2014

Li Youjun, Wei Zhiyi, Yan Yan, Wan Qingwen, Du Quansheng, Zhang Mingjie

Abstract excerpt

The Crumbs (Crb) complex, formed by Crb, PALS1, and PATJ, is evolutionarily conserved in metazoans and acts as a master cell-growth and -polarity regulator at the apical membranes in polarized epithelia. Crb intracellular functions, including its direct binding to PALS1, are mediated by Crb's highly conserved 37-residue cytoplasmic tail. However, the mechanistic basis governing the highly specific Crb-PALS1...

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Share to Cell Polarity
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Guanylate Kinases

Share to Madin Darby Canine Kidney Cells

Share to PDZ Domains

Share to Protein Multimerization

Share to src Homology Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 25385611
DOI: 10.1073/pnas.1416515111
PMCID: PMC4267380

Genes

PALS1
CASK
PATJ
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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