Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Composition and function of the Crumbs protein complex in the mammalian retina.

Experimental eye research - 1 May 2008

Gosens Ilse, den Hollander Anneke I, Cremers Frans P M, Roepman Ronald

Abstract excerpt

The Crumbs proteins (CRBs) are transmembrane proteins, homologous to Drosophila Crumbs, with a key role in defining the apical membrane domain in photoreceptors as well as in embryonic epithelia. Crumbs proteins are conserved between species and their intracellular domains are involved in organizing a conserved macromolecular protein scaffold with important roles in cell polarity as well as morphogenesis and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Disease Models, Animal
Share to Eye Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Nerve Tissue Proteins

Share to Retina

Share to Retinal Degeneration

Share to Synapses

Source

Identifiers

PMID: 18407265
DOI: 10.1016/j.exer.2008.02.005

Genes

CRB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Composition and function of the Crumbs protein complex in the mammalian retina.PMID 18407265Read ↗

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.Semantic proximity Read ↗

Towards understanding CRUMBS function in retinal dystrophies.Semantic proximity Read ↗

CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila.Semantic proximity Read ↗

Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs.Semantic proximity Read ↗

Crumbs homologue 1 in polarity and blindness.Semantic proximity Read ↗

Drosophila crumbs is required to inhibit light-induced photoreceptor degeneration.Semantic proximity Read ↗

Diverse functions and pathogenetic role of Crumbs in retinopathy.Semantic proximity Read ↗

Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal laminationSemantic proximity Read ↗

Crumbs regulates rhodopsin transport by interacting with and stabilizing myosin V.Semantic proximity Read ↗

Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres.Semantic proximity Read ↗

Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells.Semantic proximity Read ↗

CRUMBS-associated mutations in Retinitis Pigmentosa and its impact on molecular scaffolding.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.