Article
Bias Characterization in Probabilistic Genotype Data and Improved Signal Detection with Multiple Imputation.
PLoS genetics - 1 Jun 2016
Palmer Cameron, Pe'er Itsik
Abstract excerpt
Missing data are an unavoidable component of modern statistical genetics. Different array or sequencing technologies cover different single nucleotide polymorphisms (SNPs), leading to a complicated mosaic pattern of missingness where both individual genotypes and entire SNPs are sporadically absent. Such missing data patterns cannot be ignored without introducing bias, yet cannot be inferred exclusively from...
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